From Keifer's Hagiographies:
Ephrem of Edessa was a teacher, poet, orator, and defender of the Faith....Edessa (now Urfa), a city in modern Turkey about 100 kilometers from Antioch (now Antakya), was a an early center for the spread of Christian teaching in the East. It is said that in 325 he accompanied his bishop, James of Nisibis, to the Council of Nicea. Certainly his writings are an eloquent defense of the Nicene faith in the Deity of Jesus Christ. He countered the Gnostics' practice of spreading their message through popular songs by composing Christian songs and hymns of his own, with great effect. He is known to the Syrian church as "the harp of the Holy Spirit."
Ephrem retired to a cave outside Edessa, where he lived in great simplicity and devoted himself to writing. He frequently went into the city to preach. During a famine in 372-3 he worked distributing food to the hungry, and organizing a sort of ambulance service for the sick. He worked long hours at this, and became exhausted and sick, and so died.